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Researchers have indicated that when people consume a natural dietary supplement called nicotinamide riboside (NR) daily, it mimics caloric restriction (CR), kick-starting the same key chemical pathways responsible for its health benefits.Supplementation also tends to improve blood pressure and arterial health, particularly in those with mild hypertension, the study found.Nicotinamide Riboside Chloride powder

“This was the first ever study to give this novel compound to humans over a period of time,” said senior author Doug Seals, a Professor and researcher in the Department of Integrative Physiology at the University of Colorado Boulder. “We found that it is well tolerated and appears to activate some of the same key biological pathways that calorie restriction does.”Dr Seal and lead author Chris Martens included 24 lean and healthy men and women ages 55 to 79 from the Boulder area.Half were given a placebo for six weeks, then took a 500 mg twice-daily dose of nicotinamide riboside (NR) chloride (NIAGEN). The other half took NR for the first six weeks, followed by placebo.The researchers took blood samples and other physiological measurements at the end of each treatment period. Participants reported no serious adverse effects.

The researchers found that 1,000 mg daily of NR boosted levels of another compound called nicotinamide adenine dinucleotide (NAD+) by 60 percent. NAD+ is required for activation of enzymes called sirtuins, which are largely credited with the beneficial effects of calorie restriction. It’s involved in a host of metabolic actions throughout the body, but it tends to decline with age.

Research suggests that as an evolutionary survival mechanism, the body conserves NAD+ when subjected to calorie restriction. But only recently have scientists begun to explore the idea of supplementing with so-called “NAD+-precursors” like NR to promote healthy ageing.“The idea is that by supplementing older adults with NR, we are not only restoring something that is lost with ageing (NAD+), but we could potentially be ramping up the activity of enzymes responsible for helping protect our bodies from stress,” Martens said.

The new study also found that in 13 participants with elevated blood pressure or stage 1 hypertension (120-139/80-89 mmHg), systolic blood pressure was about 10 points lower after supplementation. A drop of that magnitude could translate to a 25 percent reduction in heart attack risk.“If this magnitude of systolic blood pressure reduction with NR supplementation is confirmed in a larger clinical trial, such an effect could have broad biomedical implications,” the authors note.

Ultimately, the authors say, such CR-mimicking compounds could provide an additional option–alongside the dietary changes and exercise currently recommended–for people whose blood pressure is not yet high enough to warrant medication but who are still at risk for a heart attack.

“We are not able to make any definitive claims that this compound is safe or going to be effective for specific segments of the population,” said Dr Martens, now an Assistant Professor at the University of Delaware. “What this paper provides us with is a really good stepping stone for future work.”

Dr Martens and Dr Seal have applied for a grant to conduct a larger clinical trial looking specifically at the impact of NR supplementation on blood pressure and arterial health. Dr Martens is also launching a separate trial looking at the impact NR has on older adults with mild cognitive impairment, a precursor to Alzheimer’s disease.
Nefiracetam (chemical name N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide) is one of the more modern racetams and is purported to have much wider effects on brain activities than the first generation of racetams, and is considerably more potent. Unlike piracetam, it is fat soluble.Nefiracetam powder

Due to its wide ranging uses, nefiracetamis considered to be a second generation racetam. Due to its far ranging effects and possible uses, like pramiracetam it has become a popular supplement for sufferers of Alzheimer's disease and dementia.

The technical term for smart drugs is nootropics, which are a group of health supplements which are purported to increase cognitive ability, intelligence, memory, and general brain function.

As an analogue to piracetam, it is considered that nefiracetam is virtually non-toxic, non addictive, has very few side effects, and enhances verbal memory. Nonetheless, unlike piracetam there have been fewer clinical trials and research into the affects of nefiracetam, however it is widely considered to be considerably more potent than piracetam, and users of nefiracetam generally report that it improves memory, alertness, and cognitive function.

Several studies have shown that unlike the first generation of racetams (piracetam, oxiracetam, and aniracetam), nefiracetam also has a positive effect on mood, and acts as an antidepressent. It also stimulates the AMPA receptors in the brain. Substances which affect the brains AMPA receptors are known as Ampakines, and these substances have been shown to greatly increase attention span, learning ability, altertness, and general cognitive functions.

As with all of our racetams, nefiracetam is very popular among students, sufferers of Alzheimer's and dementia, those recovering from alcoholism, and life extension enthusiasts.

As with most all racetams, nefiracetam should be taken with a choline source such as choline bitartrate. It is also often ‘stacked’ with other racetams as well as with supplements such as GABA, and L-Tyrosine, and L-Phenylananine.

9-Me-BC powder is a methylated derivative of β-carboline with the molecular formula C12H10N2. It may be prepared by preforming the Eschweiler–Clarke reaction on freebase β-carboline (norharmane).beta carboline powder

In vitro studies with dopaminergic neuron cell cultures demonstrated increased expression of tyrosine hydroxylase and associated transcription factors, increased neurite outgrowth, regeneration of neurons after chronic rotenone administration, and reduced expression of inflammatory cytokines. In studies of primary mesencephalic dopaminergic neuron cell cultures, the substance increased the number of differentiated dopaminergic neurons and produced higher levels of transcription factors associated with dopaminergic differentiation.[2] 9-Me-BC also inhibited the oxidation of the neurotoxin precursor MPTP to the dopaminergic neurotoxin MPP+ in vitro.

Rodent studies in vivo demonstrated elevated hippocampal dopamine levels, improved spatial learning performance in a radial maze test, and increased dendrite outgrowth in the dentate gyrus of the hippocampus, as well as restoration of the number of tyrosine hydroxylase expressing neurons in the left striatum after an injection of MPP+ had reduced the number of such cells by 50% in an animal model of Parkinsonism.
β-Carbolines (BCs) belong to the heterogenous family of carbolines, which have been found exogenously, that is, in various fruits, meats, tobacco smoke, alcohol and coffee, but also endogenously, that is, blood, brain and CSF. These exogenous and endogenous BCs and some of their metabolites can exert neurotoxic effects, however, an unexpected stimulatory effect of 9-methyl-β-carboline (9-me-BC) on dopaminergic neurons in primary mesencephalic cultures was recently discovered. The aim of the present study was to extend our knowledge on the stimulatory effects of 9-me-BC and to test the hypothesis that 9-me-BC may act as a cognitive enhancer. We found that 10 days (but not 5 days) of pharmacological treatment with 9-me-BC (i) improves spatial learning in the radial maze, (ii) elevates dopamine levels in the hippocampal formation, and (iii) results after 10 days of treatment in elongated, more complex dendritic trees and higher spine numbers on granule neurons in the dentate gyrus of 9-me-BC-treated rats. Our results demonstrate that beyond its neuroprotective/neurorestorative and anti-inflammatory effects, 9-me-BC acts as a cognitive enhancer in a hippocampus-dependent task, and that the behavioral effects may be associated with a stimulatory impact on hippocampal dopamine levels and dendritic and synaptic proliferation.
We all at one point find ourselves working through the night shift, beating strict deadlines, or even burning the midnight oil for the sake of a test. So, what is the first thing that comes to your mind when thinking about any of these tasks? I bet you thought about a cup of hot concentrated coffee or some energizing drink.Well, nootropics are not your typical cup of caffeine. They do more than stimulating your brain, stirring up insomnia, and causing annoying jitters.oxiracetam buy

A single dose is enough to increase your intellect, power up your cranial capacity, and improve your learning ability. This fact seems too good to be true, right? Hold your horses because there are several successful clinical trials to it back up. After all, medical doctors discovered the potency of racetams and gave it a go when managing patients with dementia, ADHD, and Alzheimer’s.

Are you looking to go beyond your limits? Before you swallow this limitless pill, let’s find out if the drug is worth it.Racetams are synthetic compounds belonging to the Nootropic Family. The group comprises of over 15 different chemicals. They all feature two pyrrolidone nucleus with oxygen, hydrogen, and nitrogen molecules.

Although they share a chemical backbone, each racetam has a parallel function. The differences in the structural orientation are responsible for the dissimilarities in potency, mechanism of action, metabolism, dosage, and half-life.

Racetams modulate the level of acetylcholine in the brain. The neurotransmitter accounts for most of the cognitive functions, including attentiveness, logical thinking, focus, concentration, and memory formation.

History

Racetam is the forerunner of all the other nootropics. However, its existence was coincidental.Dr. Corneliu Giurgea and his co-researchers were designing a molecule that could reverse abnormal sleep pattern and motion sickness.

However, by a twist of fate, these scientists discovered that the compound could also enhance focus and heighten the mental state of the user. Taking advantage of this side effect, Dr. Corneliu Giurgea and his team set out to investigate the role of racetams in cognition and brain functionalities.

Upon the successful discovery, piracetam became the godfather of the racetam family. This invention occurred in 1964. Subsequently, researchers saw the need to improve this generic smart drug and came up with superior versions, including Oxiracetam nootropics.
Oxiracetam is one of the compounds found in the Racetam family, and is one of the most well-established Nootropic compounds available. Oxiracetam has shown the ability to benefit learning ability, retention of memory, sociability, and also offers neuroprotective and neuroregenerative benefits to those suffering from dementia 1. Oxiracetam is a synthetic Nootropic that is not found naturally in nature or food and is water soluble. A typical Oxiracetam dosage ranges from 300-750mg, although there are many accounts of those taking doses greater than 1g without unpleasant side effects.oxiracetam

Benefits of Oxiracetam

Oxiracetam is thought to act on the acetylcholine and cholinergic pathways of the brain. This provides a stimulating effect that isn’t typically mood-affective like other racetams like Aniracetam. Oxiracetam is currently considered a non-food, unapproved drug by the FDA and therefore exists in a bit of a regulatory grey area. Oxiracetam has been widely investigated for its application in the reduction of dementia-related symptoms, as well as its ability to offer neuroprotective action. Results vary, but Oxiracetam is generally regarded as being able to offer much benefit to those suffering with dementia, and typically over the age of 65. Clinical data regarding Oxiracetam usage in humans is lacking to make any broad-sweeping claims as to the benefit of this compound, but several animal studies have shown highly–beneficial neuroregenerative action and neuroprotective action seen with the administration of Oxiracetam 2.

Oxiracetam is regarded as offering the ability to greatly enhance the logical, decision–making capacity of the mind
Anecdotal evidence, much of which is taken from online accounts of individual user experiences, illustrates a very exciting range of potential benefits offered by Oxiracetam. Oxiracetam is regarded as offering the ability to greatly enhance the logical, decision–making capacity of the mind and many users describe a more ‘level-headed’ approach in decision making. Oxiracetam is regarded as being a memory-enhancing compound, especially with regards to long-term memory formation and the absorption of new information. Oxiracteam is also known to increase attention span, improve the speed at which one is able to process information, and generally improve the overall learning ability of the user. For these reasons, Oxiracetam is often preferred by many academic users in place of more extreme alternatives such as Adderal, Vyvanse, and Ritalin.

Oxiracetam vs Aniracetam
Oxiracetam and Aniracetam are both known to exhibit stronger overall effects than Piracetam, and are generally regarded as both being among the most popular of all Racetam Nootropics. Oxiracetam is known to be more stimulating than Aniracetam, and also less-affective towards mood and emotions. Oxiracetam is generally taken by people who have issues responding to Piracetam, or simply want more pronounced effects. The experience of Oxiracetam is often summarized as a generalized stimulation of mental energy, and is interpreted by many as having a slightly anxious ‘edge’ in some cases. Aniracetam is a fat-soluble compound and must be taken with fats, or with a meal, to be properly absorbed by the body. Oxiracetam is water soluble and can easily be administered between meals and is easily mixable in a glass of water.
Higher consumption of tomatoes could be associated with a decreased risk of liver cancer caused by high-fat diets, a study has found.The study, conducted on mice, showed that tomatoes are rich in lycopene -- a strong antioxidant, anti-inflammatory and anti-cancer agent -- which helps in effectively reducing fatty liver disease, inflammation and liver cancer development.Lycopene powder

"Consuming whole foods like tomatoes and processed tomatoes from sauces, tomato paste, canned whole tomato products, ketchup and juice, provides the best source of lycopene," said Xiang-Dong Wang, Professor at Tufts University in the US.

Interestingly, we observed that tomato powder is more effective than the same dose of purified lycopene supplementation to prevent liver cancer development, said Wang.This could be due to the potential beneficial effects of other nutrients in a whole tomato, such as vitamin E, vitamin C, folate, minerals, phenolic compounds and dietary fibres.

In addition, feeding mice tomato powder increased the richness and diversity of beneficial microbiota and prevented the over-growth of some bacteria related to inflammation, said the study, published in the journal Cancer Prevention Research.

For the study, infant mice were infected with a liver carcinogen and then fed an unhealthy high-fat diet similar to a Western diet, with or without tomato powder containing lycopene.Other foods including guava, watermelon, grapefruit, papaya, and sweet red pepper also contain lycopene, but in much lower concentrations compared to tomatoes.

Eating tomatoes and tomato products such as tomato sauce rich in lycopene is also associated with a lower risk of cardiovascular disease, osteoporosis, diabetes, and certain cancers, including prostate, lung, breast and colon cancer, the study showed.
3-O-Ethyl-L-Ascorbic Acid, or Ethyl Ascorbic Acid is a molecule produced by modifying Ascorbic Acid, commonly known as Vitamin C. This modification is done to increase the molecule’s stability and enhance its transport through skin, as pure Vitamin C is easily degraded. In the body, the modifying group is removed and Vitamin C is restored in its natural form. Thus, Ethyl Ascorbic Acid retains the benefits of Vitamin C, such as antioxidant activity. Furthermore, it is even more potent in reducing skin darkening after UV exposure. It even has some additional effects, not observed in pure Ascorbic Acid, such as promoting nerve cell growth or reducing chemotherapy damage. Finally, the slower release also ensures that no toxic effects are observed when using this Vitamin C derivative.3-O-Ethyl-L-Ascorbic Acid

3-O-ethyl-L-ascorbic acid is an ethered derivative of ascorbic acid,the most excellent derivative of ascorbic acid so far. It is very stable in chemical structure, a real stable and discolored derivative of ascorbic acid, but also it can enter into skin and be metabolized by body as ascorbic acid. So its effect is better than pure ascorbic acid. 3-O-ethyl-L-ascorbic acid is a unique lipophilic and hydrophilic material, easily used in cosmetic formulation. The most important is that 3-O-ethyl-L-ascorbic acid can easily enter into dermis and play biological effect, while pure ascorbic acid almost does not enter into dermis. 3-O-ethyl ascorbic acid is an excellent choice for cosmetic chemists.

l-ascorbic acid (AA), commonly known as vitamin C, has been widely used in topical formulations for many years as an antioxidant and anti-aging ingredient. However, the physicochemical properties of AA are not optimal for skin uptake and the molecule is also unstable, readily undergoing oxidation on exposure to air. The compound 3-o-ethyl-l-ascorbic acid (EA) has been developed as a stable vitamin C derivative and has been used in topical products.
Global Market Insights, Inc. has announced the launch of ethyl ascorbic acid market, a comprehensive study enumerating the latest price trends and pivotal drivers rendering a positive impact on the industry landscape. Further, the report is inclusive of the competitive terrain of this vertical in addition to the market share analysis and the contribution of the prominent contenders toward the overall industry.86404-04-8

Ethyl Ascorbic Acid Market size is mainly driven by growing concern about physical appearance coupled with development of skincare. Ethyl ascorbic acid or 3-O-ethyl-L-ascorbic acid is a stable derivative of ascorbic acid. It offers the benefits of vitamin C to the skin and helps in reducing skin darkening caused by excessive exposure to ultraviolet rays. Owing to anti-tanning properties, it also finds applications in sunscreen products.
The organic skin care market is expected to grow at a CAGR of over 18% over the forecast timeframe. Inclination towards organic products in European countries is expected to fuel ethyl ascorbic acid market growth. Additionally, growth in the consumption of skincare products in countries, like Germany, France, and the UK, is expected to further escalate the Europe ethyl ascorbic acid industry.

The structure of the acid is relatively stable when compared to vitamin C as ethyl group forms an ether with the 3-hydroxy(OH) group of ascorbic acids. Other derivatives of ascorbic acid, such as ethers at 2-hydroxy(OH) place, can be commercialized. It enhances the skin tone and has a whitening effect; hence, it is used as an active ingredient in skin whitening products. A rise in demand for cosmetic products will drive the ethyl ascorbic acid market demand.
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The global skin care market size was estimated to be USD 115 billion in 2015 and will be worth about USD 190 billion by 2024. An increase in spending power coupled with awareness about the skin care products in Asian nations will enhance ethyl ascorbic acid market demand.

Consumption growth of personal care products with increasing applications will drive ethyl ascorbic acid market growth. The product is more beneficial than the natural vitamin C and excessive application does not cause harm to the skin. Its content in personal care products ranges between 0.5% to 10%.Growth in the consumption of skin whitening products is trending in Asian countries such as India and China. The skin care industry in India is expected to grow at a CAGR 30% by 2024 owing to the desire for fair skin. Growth in domestic skin care and cosmetic industries will further drive ethyl ascorbic acid market growth.

Topical application of the product may cause side effects on the skin, such as peeling, loosening, and allergy, due to forceful rubbing of the product leading to lymph secretion in the upper layer of the skin. This may act as a challenge to the market growth. Also, the presence of imitation products may act as a restraint to ethyl ascorbic acid market growth.

Some of the key industry players of ethyl ascorbic acid market are Yantai Aurora Chemical Co., Ltd., Parchem Fine & Specialty Chemicals, Vantage Specialty Ingredients, Gfn-Selco, BulkActives, DSM Nutritional Products AG, M.C.Biotec, Inc., GREAF, Gonmisol, Rhino Linings Corporation, and Nippon Fine Chemicals.
MALE ESTROGEN BLOCKER - When a man’s body has excess estrogen, men can experience many unfavorable, embarrassing side effects. Chrysin is a aromatase inhibitor that helps prevent the conversion of testosterone to estrogen allowing your testosterone levels to increase. Chrysin powder

LOW TESTOSTERONE? - If you are feeling the effects of low testosterone (low sex drive, fatigue, hair loss and more), there is a possibility that aromatase could be the culprit. Chrysin cream can help inhibit aromatase from converting your testosterone into estrogen. Blocking aromatase activity can provide a natural youthful boost to your testosterone level and an overall improvement in your well being.

CHRYSIN CREAM IS MUCH MORE EFFECTIVE - Estrogen Block cream more effectively delivers chrysin’s aromatase inhibiting benefits to your body than pills, capsules and powders to. Creams bypass the stomach and liver minimising gastric degradation and first pass metabolism. Much smaller amounts of chrysin are needed to provide better estrogen blocking results.

HOW TO USE ESTROGEN BLOCK - Apply 1/4 teaspoon (2 pumps) of Estrogen Block cream daily for the first 2 weeks (50 mg Chrysin daily); then apply 1/2 teaspoon (4 pumps) of cream daily (100 mg Chrysin daily) . Maximum suggested dose is 1 teaspoon (8 pumps) which equals about 200 mg daily dose. Once you have used the chrysin cream for 2 months or so, you should go for a hormone test to evaluate your estrogen / testosterone levels and if there is no change then you can increase the dose.

Men can experience estrogen dominance when excess aromatase enzyme activity occurs. Chrysin (Passion Flower Extract) can be extremely beneficial to men who are looking to regulate the testosterone / estrogen balance in their body and recapture the “vigor” of their youth. The use of this extract can result in the following positive effects in male patients:

Balance Estradiol / Estrogen
Boost Testosterone
Greater stamina
Increased mental clarity
Higher energy levels
Increased libido
Greater muscle tone
Greater mood
GHS H Statement:
Causes serious eye damage.
Harmful if swallowed.
Causes severe skin burns and eye damage.

GHS P Statement:
IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
Wear eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Immediately call a POISON CENTER or doctor/physician.N-Phenyl-N-(4-piperidinyl)propanamide HCL powder
IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
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